Bringing a solution to Sickle Cell Crisis - A problem 7300 years old
Pioneering discoveries for a better tomorrow
About Sickle Cell Discovery
Changing the Paradigm
Dr Sota Omoigui’s Discovery has come to offer a solution to a problem 7300 years old. It is bringing a Paradigm Shift that will save and change lives.
From a reactive treatment approach of the last 100
years of modern medicine, wherein patients are
treated in a hospital after going into an irreversible
sickle cell crisis, experiencing severe pain and multi
organ damage and death
To
A preventive symptomatic approach where home
oxygen restores reversible sickle cells to their normal
discoid shape, prevents and stops a crisis in the golden half hour, making hospitalizations few and far between, changing lives all over the world.
Home Oxygen in the Golden Half Hour
Restores reversible sickle cells to their normal discoid shape and prevents or stops a sickle cell crisis.
Guide to Using Oxygen
Home Oxygen to prevent and stop a sickle cell crisis in the golden half hour
Join the Movement - the solution is here!!
Now there is a solution, the Movement begins!!
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Sickle Cell Discovery
4019 West Rosecrans Avenue, Hawthorne, California 90250, United States
Call for Appointments - (310) 675-9121
Hours
Open today | 09:00 am – 05:00 pm |
Transforming Medical Discoveries
The Discovery
Let Oxygen be your medicine. The first discovery in 7300 years to prevent and treat a sickle cell crisis in the golden half hour.
Home Oxygen Intervention Podcast
Home Oxygen used in the golden half hour, will restore reversible sickle cells to a normal discoid shape and prevent a sickle cell crisis.
About the Discoverer, Dr Sota Omoigui
Sota Omoigui M.D. is medical director of the L.A. Pain Clinic in Hawthorne, California. He is board certified in Anesthesia with subspecialty certification in Pain Medicine. He has served as an adviser to the United States, FDA Advisory Committee on Anesthetics and Life Support Devices.
He has 1000 plus Google Scholar citations for his research work.
He is a Recipient of the US FDA Advisory Committee Service Award, in recognition of his distinguished service to the people of the United States of America
On July 4th, 2024, he described the
The First Solution in 7300 years to prevent and stop a sickle cell crisis in the golden half hour
Let Oxygen be your medicine
He is an independent translational researcher, analyzing and translating patterns in basic science research to discover novel clinical applications. He is presently the Medical Director of L.A. Pain Clinic in Hawthorne, and CEO of State-of-the-Art Technologies, Inc.
His research work in Pain Pharmacology, Anesthetic Pharmacology, Inflammation and the Inflammatory response, has also greatly impacted the medical field. Dr Sota Omoigui is a bestselling author with drug handbooks published in six languages (Indonesian, Italian, Japanese, Malaysian, Polish and Portuguese), and used by pain specialists and anesthesiologists all over the world. In his seminal book titled: The Biochemical Origin of Pain and published in 2002, he proposed his theoretical law that the origin of pain is due to inflammation and the inflammatory response. His subsequent publication of his theory as a journal article in 2007 been cited as of this date by 484 medical publications in Google Scholar. In his 2002 theory, he demonstrated a clear association between migraine and the release of inflammatory mediator calcitonin gene-related peptide (CGRP) and substance P (SP). In 2019, seventeen years later, the US FDA approved members of a new class of drugs specifically designed to treat migraine by targeting calcitonin gene-related peptide (CGRP). Those drugs have been the greatest advance in the treatment of migraine.
His Sota Omoigui’s Anesthesia Drugs Handbook as well as Sota Omoigui’s Pain Drugs Handbook, have been cited in 116 different publications in Google Scholar. Apps of his Anesthesia drug handbooks are available on the Google PlayStore and the Apple App store.
The Physics law of conservation of mass, as embodied in the equation of continuity states that, in any steady state process, the rate at which mass enters a system is equal to the rate at which mass leaves the system. Applying that law to injection procedures, Dr Omoigui has pioneered minimally invasive myofascial nerve block injection procedures utilizing a 30G 5/8 in needle to treat spinal pain and radiculopathy that hitherto required epidural injections with 3-5 inch needles. Thus democratizing the utilization of spinal injections by primary care physicians as well as physician assistants and nurse practitioners. Furthermore, based upon his theory, Dr Sota Omoigui has advocated a change in the practice of pain medicine whereby current procedural injections for back, neck and radicular pain focus on structures that are visible with imaging, skeletal system (bones, joints, intervertebral discs) and central nervous system (brain and spinal cord) components while completely ignoring the treatment of inflammation and the targeting of the largest organ in the spine and most often the initial site of injury, which are the paraspinal muscles and fascia –cervical, thoracic and lumbar.
His theory has been recently validated in 2023. As stated in the NIH, HEAL Initiative Fund Opportunity [29], the field of musculoskeletal pain has largely focused on the skeletal system (bones, joints, intervertebral discs) and central nervous system (brain and spinal cord) components. The contribution of myofascial tissues, especially fascia, and the interactions of fascia, muscles, and peripheral nerves are understudied and remain mostly unknown. Pain originating from muscles and fascia is likely an important component of many severe and chronic pain conditions. The perimuscular fascia is richly innervated with small-diameter fibers whose receptive fields increase in the presence of inflammation. Thus myofascial tissues play a significant role as pain generators.
The NIH noted that for many years, structural imaging was the main tool to guide treatment decisions, including surgery. Meanwhile, imaging and other objective measurements of “soft” tissues including muscles, and connective tissues or “fasciae,” were not even considered as musculoskeletal pain biomarker candidates. Thus NIH has called for development of biomarkers of myofascial tissues for effective pain management regimens.
His research work on sickle cell disease builds on the work by Hahn and Gillespie (1927) who suggested that hypoxia caused the sickling of red blood cells and work by Hargrave et al (2003) which concluded that, low nocturnal oxygen saturation appears to be highly significantly associated with frequent painful vasoocclusive crisis in Sickle Cell Disease. Chang et al (2024) confirmed that 43% of sickle cell patients had sufficient nocturnal hypoxemia to warrant oxygen therapy. The basic science research by Franck and Chiu (1983), Robert Hebbel (1991), Melanie Gonick (2015) combined with the clinical trial in Canada by Zipursky et al (2015) demonstrated conclusively that reoxygenation of reversible sickle cells would restore them to their normal discoid shape and Dr Sota Omoigui’s clinical research found that restoration with home oxygen would occur within the golden half hour. Subsequent to that time, and by the time patients arrive at the hospital, reversible sickle cells undergo repeated sickling, progress to irreversible sickle cells, undergo cell wall damage with cell death and can no longer be restored by oxygen. Thus leading to an intractable sickle cell crisis with the attendant complications. Dr Omoigui’s research documents a 90% decrease in sickle cell crisis when oxygen is administered at night or during daytime sleep in the presence of one or more triggers such as stress, exertion/exhaustion, increased sedation, alcohol ingestion, altitude, infection and cold environment. And advocating a standard of care protocol for sickle cell multi-organ ischemic crisis that is no less timely than the protocols for acute coronary syndromes and stroke. The patient’s physician or hospital should prioritize pain control not just to reduce pain and suffering but to prevent chest splinting, shallow breathing and decreased oxygenation that are a prequel to acute chest syndrome that is known to have 25% mortality. Pain control requires parenteral doses of pure opioids like Morphine, Hydromorphone, Pethidine, Fentanyl or the potent analgesic Ketamine. These should be combined with anti-inflammatory injections that the patient has previously tolerated. Weak opioids like Pentazocine or Tramadol should never be used in a sickle cell crisis. Pentazocine is banned in the United States for its psychiatric side effects.
Dr. Sota Omoigui pioneered the technique of audio-capnometry and holds a United States patent for the audio-capnometer monitor and a United States patent for the process of continuous non-invasive hemometry (measurement of hemoglobin). He also holds 5 United States patents for the Xchange Mall – Super App, a social media app that he developed.
Dr Sota Omoigui is one of the five co-authors of the All Nigerian National Anthem. The anthem was adopted in 1978 and replaced the previous national anthem, “Nigeria, We Hail Thee“. The lyrics are a combination of words and phrases taken from five of the best entries in a national contest. The words were put to music by the Nigerian Police Band under the directorship of Benedict E. Odiase. Dr Sota Omoigui’s contribution is a legacy for years to come.
Research interests
Dr Sota Omoigui’s research focus is on analyzing and translating patterns in basic science research to discover novel clinical applications.
On April 11th, 2002, Dr Sota Omoigui published his Law of Pain which states: – The origin of all pain is inflammation and the inflammatory response. This is the most significant advance in our understanding of Pain since the 1965 publication of the Gate Theory of Pain by Ronald Melzack and Patrick Wall.
The Discovery
At Sickle Cell Discovery, we're committed to changing the paradigm of sickle cell crisis. Dr Sota Omoigui's discovery has come to offer a solution to a problem 7300 years old.
Podcast - First Radio Broadcast of Dr Sota Omoigui's Discovery
Home Oxygen used in the golden half hour, will restore reversible sickle cells to a normal discoid shape and prevent and stop a sickle cell crisis in the golden half hour.
Podcast - February 27th, 2025 Radio Broadcast of Dr Sota Omoigui's Discovery
Home Oxygen used in the golden half hour, will restore reversible sickle cells to a normal discoid shape and prevent and stop a sickle cell crisis in the golden half hour.
Transforming Medical Discoveries
Predicting behavior of Sickle Cells - MIT
See Oxygen in the golden half hour, revive reversible sickle cells back to life and restore them to a normal discoid shape and back to flowing freely through the blood vessels.
Video Produced and Edited by Melanie Gonick/MIT Additional footage courtesy of Ming Dao
Patients with sickle cell disease often suffer from painful attacks known as vaso-occlusive crises, during which their sickle-shaped blood cells get stuck in tiny capillaries, depriving tissues of needed oxygen. Now, researchers from MIT, CMU and UPitt have developed a tiny microfluidic device that can analyze the behavior of blood from sickle cell patients.
Prevention and Clinical Management of Sickle Cell Crisis
Prevention
Home Oxygen - Used to sleep when there are daytime stressors
Supplemental Oxygen for Air Travel and in high altitudes
Treatment
Home Oxygen used to stop a crisis in the golden half hour (30 mins) of onset of pain. If the crisis does not stop, please proceed to the hospital as you may be having an infection, malaria or hemolysis
Hospital Pain Control
Proper and rapid control of pain is critical to alleviate suffering and more importantly to prevent acute chest pain syndrome resulting from chest splinting and shallow breathing leading to low oxygenation. Acute chest syndrome has 25% mortality. Pain Control is achieved by the use of pure opioids like Morphine, Pethidine, Hydromorphone and potent analgesics like Ketamine. These should be combined with anti-inflammatory drugs like Diclofenac or Ketorolac. Weak opioids like Pentazocine or Tramadol should never be used to treat the pain of a sickle cell crisis. Pentazocine also has psychiatric side effects and is banned in the United States.
Hospital Fluid Management
Sickle Cell patients have increased risk of pulmonary edema due to diastolic dysfunction. Monitor fluid input and output. Also include the amount of blood transfused. Pulmonary edema can be confused with acute chest syndrome and both have a high mortality rate.
Innovative Research Areas
We are at the forefront of cutting-edge research in a variety of areas, including cancer, infectious diseases, neurology, and more.
Partnerships and Collaborations
We are proud to partner with leading organizations in the medical research and development industry to advance the field and bring new treatments and technologies to patients around the world.
Video and chat testimonies
WhatsApp Chat Testimonies on Dr Sota Omoigui's Discovery
Chat Testimonies on Dr Sota’s Discovery - Let Oxygen be your Medicine
Good morning doctor, I am so greatful and honored by your invitations sir , however timing may be factor while it may be a little difficult to join the meeting sir , Like as I told you before ,I based in south africa while my family based in Lagos Nigeria, and I am a handy work man electrician by the way sir, yeah I did discussed your invitation with my wife she promised to do a video testimony of oxygen , however
The oxygen has been a lot of relief to my family , yeah my boy was born 2005 very handsome and intelligent, his growing up no sign of sickle cell disease until 2022 when he gained admission to sturdy medicine in benin University, and after 6 months to 8 months of him in farign land he started sick day in dey out ,when they take him to the hospital by the school they will give him treatment and bills me , at a time I decided to ask him to return back to Nigeria to get proper treatment of materials, when he come back the hospital discovered they was no blood on him and they started runing test ,on the process ,it was discovered the sickle cell anemia disease, sir this is how our problem started , every week we are in hospital and he stopped going to school ,crisis every month or 2 weeks , from that 2022 the problem was out of this world , no hospital who doesn't know my wife ,and when this crisis started it usually take one week or more to relief him , if you around doctor you will cry ,I don't think they is any pain greater than the pains of sickle cell disease, doctors in Nigeria some doesn't care this is why my wife with few of this individuals doctors fights, however 3 months ago ,I saw your advert through a town guy who based in America that discussed issue of sickle cell patience, and I follow him and called the guy and the said he was going to contact you and the guy name is tonna,and he called me back and give me a link to follow and which I did and followed your teaching the post ,initially I wasn't understanding coz I have issue of reading with understanding, I kept on asking questions that was not following to the teaching, coz I was think they was hospital you going to refer us and we Wil pay a setting amount he will get treated , until a good lady that I am still talking with in this group called me privately and explained the whole thing about the oxygen and give me the address where to purchase, which I purchased immediately and the delivery was made after the payment , now when ever he has small pains and my wife plugs the oxygen which has been our medicine since 3 months, he will fail sleep by the time he wake up he will get better immediately ,sir we really happy with you , ever since then no going to hospital ,he is big fat ,you will never agreed he was that parson that sick every week , doct we will make time and do a proper video of this, he does everything people do ,he drive and go out ,he was telling me that he want to start online business , I am going to make a proper video of this whole thing to encourage people about the oxygen and the work sir.
Other Testimonies
Our testimony:
Good afternoon Dr Sota. I am in the United States.My son is four years old with sickle cell anemia.
He was diagnosed through the new born screening. The drs here have had him on hydroxy urea medication and penicillin prophylaxis since he was about 18 months. While he hasn’t complained about pain much, he has however been hospitalized several times since birth for mainly acute chest / pneumonia.
Last year he was hospitalized more than six times for acute chest.
Due to your direction, my husband and I got the oxygen concentrator in March this year and since then, he hasn’t been hospitalized at all, which is the longest time we’ve gone without hospitalization.
Our approach has been that whenever we feel his fever coming on, we’ve immediately put him on the oxygen or overnight when his breathing b is shallow. We are certain the oxygen has played the crucial role in reducing our hospitalizations.
Thank you so much Dr. Sota Omoigui for this knowledge and direction on the use of oxygen to manage sickle cell crisis. It is certainly changing our lives.
Testimony
Good day Dr. Sota. May God bless you real good. Pls, my son Haa been using the oxygen tank since October last year n has successfully combated 2 crises. Initially, he was skeptical about using it. But after using it 2ce, it really boosted his confidence and outlook towards life. Thanks so much for that. Last weekend, he had an onset of crises n started using the oxygen tank, however, it was exhausted before he got relief from the pain. We had to result to using on pain medication. Thank God he wasn't hospitalised. We're considering buying a second cylinder as spare. We can't afford the oxygen generator for now.
Testimony
Good afternoon Sir,l just wanted you to know my son started complaining of pain this morning,l stopped him from going to school and had him use the concentrator like that at the 78 percent purity for 2litres and after a short nap.He felt energized and better.l think your discovery may be a major game changer even though we are yet to get a better concentrator as prescribed by you.l will keep you posted on his health and let you know how he is doing once l buy another one.[1:47 AM, 1/29/2025] Dr Sota Omoigui: I don't know what I will buy for you but if this works out the way l suspect it will,l will forever be in your debt. .
Testimony
Good evening @Dr Sota Omoigui I just want to use this medium to appreciate your discovery and I will say it really working.actually am a nurse and came across an 11yrs old boy who was experiencing voc and he was rushed to the hospital were i worked and I told my charge nurse we should administer oxygen immediately but she was after the pain,how to reduce the pain but kept on pressing until she agreed to my opinion and I assured her that with the administration of oxygen the pain will go away, she didn't believe how everything happened immediately we commence the oxygen administration
Testimony
Dr Sota Omoigui: I am a mother of 2 warriors who found out about home oxygen in December. THIS WORKS!!! We have decreased hospital visits and and pain medicine administered in the 5 months we have had the machine! I found a brand new one on eBay it was Gods plan. I hope everyone and anyone will try this and have better results in their daily lives. iThank you Dr. Sota!!
Testimony
Dear @Dr Sota,
You may remember that some time ago, I informed you that I'd purchased a POC and that I was going to spend time to observe its effectiveness in the prevention/ abortion of a sickle cell crisis.
Since then, I've been quiet, just to enable me have an honest assessment.
I am pleased to inform you that beyond any reasonable doubt, I can claim unequivocally that I ve found its usage worthwhile in the 2 respects stated above (prevention & abortion). Since that time, my 2 SCD kids have not had an attack serious enough to warrant going to the hosp. This, compared to the past when the average frequency was once or twice in a month, is certainly good news.
I have, since then, been spreading the good news to whoever cares to listen.
Kudos to you, my brother, for the time, zeal and passion you are putting to alleviate the pains and suffering that SCD patients and their families go through.
We truly can't thank you enough.
Testimony
Good morning, sir Dr Sota Omoigui: I just want to say thank you. It's been 3+ months since we got a concentrator, and it's been 3+ months of no crisis or pains. God is using you to do amazing things for people all over the world. GOD BLESS YOU, SIR.
Recommended Centers for Sickle Cell Care
Providing Home Oxygen and Compassionate Care
Paelon Memorial Hospital
Plot 1221 Ahmadu Bello Way
Victoria Island, Lagos
Mobile: +234 901 112-2219 (WhatsApp)
Ph: +234 912 512-0020
Contact: Dr Ngozi Onyiai
Website: paelonmemorial.com
https://maps.app.goo.gl/VfpmyNLeRp4eXKD98?g_st=iw
Patient-Focused Research
At Sickle Cell Discovery, we're committed to putting patients first. Our research is designed to improve patient outcomes and provide better treatment options for a wide range of medical conditions.
Collaborative Partnerships
We believe that the best results come from working together. That's why we collaborate with other research institutions, medical centers, and pharmaceutical companies to achieve our goals.
Innovative Solutions
We're always looking for new and innovative ways to approach medical research. Our team is constantly exploring new technologies, techniques, and approaches to achieve our goals.
Industry Recognition
Our groundbreaking research has earned us recognition as leaders in the medical research and development industry. We're proud to have been recognized with numerous awards and accolades.
Resources for Sales and Repair of Oxygen Concentrators
Lagos
Code Run Medical Oxygen Supplies
Plot 360 Alakoso Avenue, Amuwo Odofin
Lagos
Contact: Kunle
Ph: +234 803 341 0877
Abuja
Bijoh Surgical and Scientific Company
Ste A1, Ground Floor
Onitsha Crescent
Victory Plaza, Gimbiya Street
Garki, Abuja
FCT
Ph: +234 905 388-5888 : +234 807 129-2888
Abuja
Lagos
Eagle Hospital and Health Consultancy Services
35 Charity Road, Opposite Old English Supermarket Bakery
Abule Egbe / New Okoba
Lagos
Ph:+ 234 802 321-6655 +234 905 096-9280
Contact: Dr Ernest Onogu
Lagos
ERS Nigeria Limited
45B Aba Johnson Crescent
Adeniyi Jones Avenue
Ikeja, Lagos, Nigeria
Mobile: +234 809 631-8332 (WhatsApp)
Tel: +234 8099930457
Contact: Tola Alabi
E-mail: sales@ersltdng.com
Website: www.ersltdng.com
Lagos
Paelon Memorial Hospital
Plot 1221 Ahmadu Bello Way
Victoria Island, Lagos
Mobile: +234 901 112-2219 (WhatsApp)
Ph: +234 912 512-0020
Contact: Dr Ngozi Onyiai
Website: paelonmemorial.com
https://maps.app.goo.gl/VfpmyNLeRp4eXKD98?g_st=iw
Innovative Solutions
We're always looking for new and innovative ways to approach medical research. Our team is constantly exploring new technologies, techniques, and approaches to achieve our goals.
Industry Recognition
Our groundbreaking research has earned us recognition as leaders in the medical research and development industry. We're proud to have been recognized with numerous awards and accolades.
Recommended Oxygen Concentrators
Liberty 2 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
Sequal Eclipse 5 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
Sequal Eclipse 5 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
6.35 lbs weight
Continuous Flow - 0.5-2 liters per minute.
Oxygen Purity 87% - 95% at sea level at all settings
Built in swappable battery. 4.5 hrs (pulse) 1-2 hours (continuous)
Website:
Sequal Eclipse 5 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
Sequal Eclipse 5 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
Sequal Eclipse 5 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
18 lbs weight
Continuous Flow - 0.5-3 liters per minute
Oxygen Purity - 90% +5.5/-3%
Built in swappable battery.
Website: https://www.caireinc.com/product/sequal-eclipse-5/
.
Wellue Home Oxygen Concentrator - Not FAA Approved
Sequal Eclipse 5 - Continuous Flow Portable Oxygen Concentrator - FAA Approved
GCE Zen-O Portable Oxygen Concentrator - FAA Approved
33lbs weight
Continuous Flow -0.5-5 liters per minute
Oxygen Purity - 93%±3%
No Rechargeable battery. AC Power only.
Website
https://getwellue.com/products/5l-oxygen-concentrator
GCE Zen-O Portable Oxygen Concentrator - FAA Approved
GCE Zen-O Portable Oxygen Concentrator - FAA Approved
10.27 lbs weight
Continuous Flow - 0.5-2 liters per minute.
Oxygen Purity 87% - 96% at all settings
Built in rechargeable battery. 45 min (2 L/min continuous 1 battery; 1.5 hrs (2 batteries)
Website:
https://www.gce-medical.com/en-us/products/zen-o-portable-oxygen-concentrator
CAIRE NewLife Intensity Home Oxygen Concentrator - Not FAA Approved
58 lbs weight
Continuous Flow - 2-10 liters per minute.
Oxygen Purity 92%+3.5/-3% at 2-9 lpm
No rechargeable Battery. AC Power only.
Website:
Brivelle - 1L-8L/2-9L Home Oxygen Concentrator - Not FAA Approved
- 11.9 lbs weight
- Continuous Flow Rate: 1-8L/min
- Oxygen Purity: 93% ± 3%
- Rechargeable
- Website: https://brivelle.co.uk/product/1l-8l-2-9l-oxygen-concentrator-with-atomization/
Longfian Jay-3EW Home Oxygen Concentrator - Not FAA Approved
- 26.4 lbs weight
- Continuous Flow Rate: 0.5-3L/min
- Oxygen Purity: 93% ± 3%
- No Rechargeable battery. AC Power only.
- Website: https://www.longfian.com/product/view_246.html
Owgels OZ-5-01ZW0 Home Oxygen Concentrator - Not FAA Approved
- 39 lbs weight
- Continuous Flow Rate: 5L/min
- Oxygen Purity: 93% ± 3%
- No Rechargeable battery. AC Power only.
- Website: http://www.owgels.com/ge/goods/goods-detail-351.html
OxLife Independence Portable Oxygen Concentrator - FAA Approved
OxLife Independence Portable Oxygen Concentrator - FAA Approved
- 19.4 lbs weight
- Continuous Flow Rate: 0.5-3L/min
- Oxygen Purity: 93% ± 3%
- Rechargeable battery. AC Power only.
- Website: https://www.o2-concepts.com/products/#Independence